How Does the Oncotype DX Test Work?

How do you explain the Oncotype DX test to your patients?

oncotype DXThe Oncotype DX test is changing the way doctors treat various cancers. The ins and outs of the assay are complicated and can be difficult to explain. Essentially, the Oncotype DX test helps doctors see the genetic makeup of individual cancers. This information allows doctors to predict how different cancers will respond to treatment. Dr. Mark Kozloff tells us how doctors use this information when creating a treatment plan in this video. Better outcomes come from better information.

For more information on the Oncotype DX Colon Cancer Assay watch “Oncotype DX Colon Cancer Treatment Decision” with Dr. Mark Kozloff.

Video Transcripts

Mark Kozloff, MD: I will often sit down with the patient and discuss the pluses and minuses of going in adjuvant treatment for stage II and stage III colon cancer and what I tell them is when we order this test that it gives us more information about their prognosis and I tell them that normally when we talk about the prognosis, it is when we do an average and it tells us about a large population of patients and it does not really give me a lot of information about their cancer and that if I send off this study, I can get more information on their cancer to the prognosis, is it better than the average, not as good as the average and how that may relate to them accepting or not wanting to go on that adjuvant therapy. They may have a better idea of what the benefits are, the side effects and they can make a better informed decision about adjuvant treatment.

For an interactive tool to learn more about your colon cancer and your personalized treatment options, go to

Mark Kozloff
Dr. Mark Kozloff is board certified in Internal Medicine. He earned his degree in medicine from the University of Michigan Medical School and completed his residency at Michael Reese Hospital in Chicago. Dr. Kozloff works on a multidisciplinary team of experts in the Center for Gastrointestinal Oncology where he specializes in the treatment of colorectal malignancies.

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